Mounjaro Dose Guide UK — 2.5mg to 15mg Titration Schedule
Everything you need to know about Mounjaro (tirzepatide) doses in the UK — the standard titration schedule, what to expect at each dose, average weight loss data from clinical trials, and the current cheapest price for each dose across 63 UK pharmacies.
Prices are lowest available with discount codes as of 27 March 2026. Weight loss data from SURMOUNT-1 clinical trial (72 weeks).
Mounjaro Dose-by-Dose Breakdown
2.5mg
Starting / Titration Dose
Weeks 1–4
£121.00
cheapest/month
0–2%
avg. weight loss
The 2.5mg starting dose is a sub-therapeutic dose — it is not expected to produce significant weight loss. Its purpose is to allow your body to adjust to tirzepatide and minimise the risk of gastrointestinal side effects (nausea, vomiting, diarrhoea) that are common when starting GLP-1 treatments.
What to Expect
Mild nausea, especially in the first 1–2 weeks
Little to no weight loss at this dose
Reduced appetite beginning to develop
Injection site reactions (mild redness or bruising)
Tips
Inject on the same day each week. Eat smaller, lower-fat meals to reduce nausea. Stay hydrated.
After 4 weeks on 2.5mg, you step up to 5mg. At this dose, tirzepatide begins to have a more meaningful effect on appetite suppression. Most patients start to notice reduced hunger and some weight loss.
What to Expect
Noticeable reduction in appetite
Initial weight loss of 3–5% of body weight
Nausea may return briefly after stepping up
Improved blood sugar control (if applicable)
Tips
If nausea is significant after stepping up, discuss with your clinician — some patients benefit from staying at 2.5mg for an additional 4 weeks.
The 7.5mg dose is where many patients begin to see more significant weight loss. In the SURMOUNT-1 clinical trial, patients on 5mg and 7.5mg doses lost an average of ~15% of their body weight over 72 weeks.
What to Expect
Significant appetite suppression
Continued weight loss
Possible improvement in energy levels
Side effects typically reduce at this stage
Tips
Track your weight weekly. Ensure you are eating enough protein (at least 1.2g per kg of body weight) to preserve muscle mass during weight loss.
The 10mg dose is the first of the higher maintenance doses. Clinical trial data shows average weight loss of approximately 19.5% of body weight at this dose over 72 weeks. Many patients find this dose highly effective.
What to Expect
Continued significant weight loss
Strong appetite suppression
Possible food aversions (certain foods may become unappealing)
Most patients tolerate this dose well
Tips
Some patients choose to remain at 10mg long-term if they are achieving their goals. Discuss with your clinician whether stepping up to 12.5mg is necessary.
The 12.5mg dose produces average weight loss of approximately 20.2% of body weight in clinical trials. The incremental benefit over 10mg is modest for most patients, but some individuals respond better to higher doses.
What to Expect
Continued weight loss (may plateau for some)
Very strong appetite suppression
Possible fatigue (ensure adequate calorie intake)
Most side effects well-managed by this stage
Tips
Ensure you are not under-eating. A minimum of 1,200–1,500 calories per day is generally recommended. Work with a dietitian if possible.
The maximum dose of 15mg is the long-term maintenance dose for most patients. SURMOUNT-1 clinical trials showed average weight loss of 20.9% of body weight at this dose over 72 weeks — making Mounjaro the most effective weight loss medication currently available in the UK.
What to Expect
Maximum weight loss effect
Plateau may occur after initial rapid loss
Long-term weight maintenance
Ongoing appetite suppression
Tips
At the maximum dose, focus on building sustainable habits — exercise, sleep, and nutrition — to maintain weight loss if you ever stop treatment.
This dose guide is for informational purposes only and does not constitute medical advice. Mounjaro (tirzepatide) is a prescription-only medicine. Always follow the guidance of your prescribing clinician regarding dose titration. Do not change your dose without medical supervision. Weight loss data is from the SURMOUNT-1 clinical trial and may not reflect individual results.
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